Development and in Vitro Characterization of Niosomal Carriers Niosomal Carriers for Sustained Drug Delivery

Authors

  • Alireza Hosseinzadeh Gavon Department of Chemical Engineering, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
  • Mojtaba Khanpour * Department of Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China. https://orcid.org/0000-0002-8011-3720
  • Milad Farrokh Pour National Institute of Genetic Engineering and Biotechnology.

https://doi.org/10.48313/bic.v2i1.35

Abstract

Drug delivery systems are designed to enhance bioavailability while overcoming the limitations of conventional dosing strategies. Vesicular carriers, such as niosomes, have attracted attention for their excellent stability, cost-effectiveness, and sustained-release properties. Niosomes can encapsulate both lipophilic and hydrophilic drugs, making them versatile carriers for a wide range of therapeutics. Recent studies have focused on optimizing niosomes for targeted drug delivery, exemplified by the encapsulation of 4-Hydroxyisoleucine (4-HIL) for diabetes management. In this study, 4-HIL isolated from fenugreek seeds was incorporated into niosomes and PEGylated niosomes using the thin-film hydration method. The resulting 4-HIL-loaded niosomes exhibited semi-spherical, smooth morphologies with a particle size of ~200 nm, a Zeta Potential (ZP) of -22 mV, and entrapment efficiencies ranging from 55.1% to 87.1%. Fourier-Transform Infrared (FTIR) spectroscopy confirmed hydrogen bonding between Span 60 and cholesterol within the niosomal structure. PEGylation increased vesicle sizes to 460–580 nm and improved entrapment efficiencies to 75.43–90.1%, highlighting the potential of this formulation as a promising carrier for antidiabetic therapy.

Keywords:

Niosomes, 4-Hydroxyisoleucine, Drug delivery, Polyethylene glycol, Encapsulation

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Published

2025-03-13

Issue

Vol. 2 No. 1 (2025): Biocompounds

Section

Articles

How to Cite

Hosseinzadeh Gavon, A., Khanpour, M., & Farrokh Pour, M. (2025). Development and in Vitro Characterization of Niosomal Carriers Niosomal Carriers for Sustained Drug Delivery. Biocompounds, 2(1), 53-62. https://doi.org/10.48313/bic.v2i1.35